Rich in polyphenols & other phytonutrients

An average cup of green tea contains about 150 mg to 300 mg of polyphenols.⁶ Each capsule of this supplement provides 725 mg of green tea extract, standardized to 98 percent polyphenols. That means you'd have to drink about 3 cups of green tea to get the same number of polyphenols as a single capsule of our Decaffeinated Mega Green Tea extract.

Green tea health benefits

Protects against oxidation: Green tea polyphenols are capable of directly neutralizing destructive free radicals and are also thought to boost the body's own internal oxidative stress defenses. They've also been shown to inhibit oxidative stress.^7-9

Cellular health support: Green tea supports healthy cellular proliferation.¹ In fact, the green tea polyphenol EGCG has a remarkably broad array of cellular health benefits, exerting a positive influence on mitochondrial health, intracellular signaling pathways, intracellular messengers, transcription factors, healthy gene expression and more.¹⁰

Cholesterol management: Green tea, green tea extracts and EGCG can help maintain already-healthy blood cholesterol, LDL and triglyceride levels.^11,12

Neuroprotection and Metabolic Health: Green tea and its polyphenols, including EGCG, help protect nerve cells and nerve function, have been shown to help preserve metabolic health, and help maintain already-healthy glucose levels.^13-15

• Special time-released melatonin for all night support

An estimated 50 to 70 million American adults have difficulty sleeping. Melatonin, known as the “sleep hormone,” is made naturally by your body primarily at night and is necessary to keep our day/night rhythm in tune, but those who have trouble sleeping may not be producing enough of it at the right time. Melatonin IR/XR helps you fall asleep and stay asleep all night long. It combines immediate-release and extended-release melatonin for approximately seven hours of healthy sleep support.

Lack of quality, restful sleep can affect cognitive health, metabolic health and more. Poor sleep can mean that you have trouble falling asleep, but it can also mean that you wake up in the middle of the night and can’t get back to sleep. If that sounds familiar, try Melatonin IR/XR.

MicroActive® Melatonin

Each capsule of Melatonin IR/XR contains 1.5 mg of MicroActive® Melatonin, a unique blend of immediate- and extended-release melatonin. Taken about 30 minutes before bed, Melatonin IR/XR helps you fall asleep quickly and stay asleep all night long. Just one Melatonin IR/XR capsule provides approximately seven hours of uninterrupted sleep support, so you sleep throughout the night.

Clinical studies on standard immediate-release melatonin

Results from an analysis of 15 clinical studies show that standard melatonin helps fall asleep faster and sleep longer and promotes sleep quality compared with a placebo. In one study, subjects took a 0.1 mg, 0.3 mg, or 3 mg melatonin capsule or a placebo 30 minutes before bedtime for three days. All three melatonin doses promoted restful sleep. In a recent randomized placebo-controlled trial, subjects who took 0.5 mg fast-release melatonin at night for four consecutive weeks fell asleep faster and experienced healthy, restful sleep compared with a placebo.

Clinical studies on controlled-release melatonin

A study found that 2 mg of a controlled-release melatonin formulation taken two hours before bed promoted healthy sleep, compared with a placebo, and also shortened the length of time subjects spent awake after initially falling asleep. And in another randomized placebo-controlled study, subjects reported improvement in sleep quality after taking 2 mg of an extended-release formulation before bedtime.

Fall asleep, wake refreshed

For those who sometimes have difficulty sleeping and have tried other melatonin supplements to no avail, now there’s a new formulation from Life Extension. Get the quality, restful and uninterrupted sleep your body needs.

Suggested Use: Take one (1) capsule 30 to 60 minutes before bedtime, or as recommended by a healthcare practitioner. Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.

HMB for muscle protein balance and exercise performance

Healthy muscles depend on the natural balance between two complementary processes: anabolism, where muscle is created, and catabolism, where muscle is deconstructed. But as we age, our body's ability to build new muscle slows down—even when it has the necessary proteins and amino acid “building blocks” to do so.^5,6

The result is a decline in muscle mass and strength. HMB has beneficial effects on muscle mass by helping to preserve the structural integrity of your muscles and supporting muscle growth.^7,8 HMB also supports exercise performance during both resistance and endurance training.^9-16

HMB in clinical studies

HMB and Bed Rest: Prolonged bed rest can result in loss of muscle mass. In a randomized placebo-controlled study, men and women were confined to bed rest for 10 days, followed by eight weeks of resistance training rehabilitation. Each group took either 3 g a day of HMB or a placebo for 5 days prior to bed rest, up until the end of the study. The placebo group lost lean mass during bed rest, but those given HMB during bed rest showed no such decline.¹⁷

HMB and Resistance Training: In a randomized, placebo-controlled trial, men and women received 3 g a day of HMB, or a placebo and trained for 4 weeks. At the end of the study, the HMB group had a greater increase in upper body strength than the placebo group.¹³ In another clinical study, supplementation with 3 g a day of HMB for 9 weeks provided a substantial benefit to lower-body strength when combined with resistance training.¹⁴ 

HMB and Older Adults: In a 24-week, randomized, placebo-controlled study, adults 65 years and older were divided into an exercise group and a non-exercise group. Both groups took either 3 g of HMB twice a day or a placebo. The non-exercise group that took HMB showed signs of improved muscle health — but the exercise group's results were even better, improving measurements of muscle function and lean mass.²

Vitamin D3 for hormone health and muscle function

Vitamin D3 promotes healthy muscle function and metabolism.^4,18 Vitamin D also supports healthy mitochondrial function and energy consumption, which are likely to influence muscle strength.³ Vitamin D helps inhibit inflammatory factors to support muscle health as well.¹⁹

Mix with protein or favorite drink

Whether or not you exercise regularly, Muscle Strength & Restore Formula is an excellent addition to your daily health regimen. We've left our formula unflavored, so you can add it to a wide variety of protein shakes, drink mixes, cold water or your favorite beverage.

NIAGEN® nicotinamide riboside

NIAGEN® is a patented, clinically studied form of nicotinamide riboside, a compound that helps increase cellular levels of the NAD+ coenzyme. This is important because the NAD+ coenzyme is necessary for creating adenosine triphosphate (ATP), the compound your body uses to create cellular energy.

In a randomized controlled trial, older adults taking 250 mg of nicotinamide riboside a day experienced a 40% increase in NAD+ levels after just 30 days. Evidence from pre-clinical studies indicates that increasing NAD+ also encourages healthy metabolic and cognitive function.

Promotes healthy aging and longevity

NAD+ Cell Regenerator™ also promotes the activity of sirtuin (SIRT1 and SIRT3), essential proteins that work with NAD+ to promote healthy aging. It also enhances production and function of mitochondria, the cellular powerhouses that provide the energy you need to thrive.

NIAGEN® nicotinamide riboside

NIAGEN® is a patented, clinically studied form of nicotinamide riboside, a compound that helps increase cellular levels of the NAD⁺ coenzyme. This is important because the NAD⁺ coenzyme is necessary for creating adenosine triphosphate (ATP), the compound your body uses to create cellular energy.

In a randomized controlled trial, older adults taking 250 mg of nicotinamide riboside a day experienced a 40% increase in NAD⁺ levels after just 30 days. Evidence from pre-clinical studies indicates that increasing NAD⁺ also encourages healthy metabolic and cognitive function. This formula contains 300 mg of NIAGEN® in every vegetarian capsule.

Promotes healthy aging and longevity

NAD⁺ Cell Regenerator™ also promotes the activity of sirtuin (SIRT1 and SIRT3), essential proteins that work with NAD⁺ to promote healthy aging. It also enhances production and function of mitochondria, the cellular powerhouses that provide the energy you need to thrive.

Mitochondria are as fascinating as they are essential: They have their own set of DNA. Even the growth of new mitochondria has a name: “mitochondrial biogenesis.” Mitochondrial biogenesis is key to maintaining youthful cellular energy production. PQQ also supports mitochondrial biogenesis and encourages healthy cellular energy levels in 3 distinct ways:

Mitochondrial DNA & antioxidant protection

The enormous amount of cellular energy generated within mitochondria also exposes them to constant free radical activity. Fortunately, PQQ is a potent antioxidant, offering powerful free radical protection and maximum support for cellular energy production at the same time.⁵

Mitochondria possess their own DNA, which is different from the DNA found in a cell’s nucleus. Unfortunately, mitochondrial DNA is more vulnerable to mutations than nuclear DNA. PQQ's antioxidant potency and favorable gene expression profile help to support delicate mitochondrial DNA against oxidation.

Favorable gene expression

PQQ activates genes that promote the formation of new mitochondria.¹⁰ PQQ also beneficially interacts with genes directly involved in mitochondrial health. These same genes also support healthy sugar and fat metabolism, youthful cellular proliferation and more.^6,7,11

Other potential whole-body health benefits

PQQ may support quality, restful sleep, heart health and cognitive function, by itself and in combination with CoQ10.^8-13 Plus, when taken with CoQ10, PQQ promotes memory, attention and cognition in maturing individuals.

Pyridoxal 5’-phosphate has been shown to protect lipids and proteins against glycation reactions.^2,3 Glycation reactions occur when sugar in the blood reacts with proteins and lipids in the body. These reactions are a natural consequence of aging and result in the formation of advanced glycation end products (AGEs) throughout the body. AGEs accumulate with time and contribute to some of the effects of aging.^4,5 Inhibiting the formation of AGEs can help support many aspects of your health.⁶

By inhibiting AGE formation and working as a coenzyme in biochemical reactions, pyridoxal 5’-phosphate can support a healthy nervous system, cardiovascular and kidney function, immune and eye health, and more.^1,7,8  

In addition to this standalone product, Life Extension offers pyridoxal 5’-phosphate in two premier formulations: Life Extension Mix™ and Mitochondrial Energy Optimizer with PQQ

Lutein and zeaxanthin carotenoids

Because they are heavily concentrated in macular pigment, lutein and zeaxanthin are associated with eye health—but they are also found at high levels in the brain.¹ This is significant because three, year-long, independent studies indicate that these carotenoids enhance brain function, encouraging improved spatial memory, reasoning skills, cognitive flexibility and complex attention scores.^2-4

These positive cognitive results appeared regardless of age: healthy older adults taking lutein and zeaxanthin saw improved measurements of their ability to filter out irrelevant information while multitasking—as well as increased activity in the left prefrontal area of the brain involved in understanding verbal information, forming long-term memories, focusing on challenges and more.^2,4

Young people (ages 18 to 25) taking these carotenoid nutrients for six months also showed improved cognitive performance, as well as healthy levels of brain-derived neurotrophic factor (BDNF ).⁵ BDNF promotes neuronal plasticity: your brain’s ability to learn by growing new connections and reorganizing old ones—a process which is essential to healthy learning and memory formation.⁵

Gotu kola (Centella asiatica)

Gotu kola has been the subject of extensive research: More than 11 randomized controlled trials have assessed the impact of C. asiatica on cognitive function.⁶ However, it’s important to understand that traditional gotu kola extracts aren’t standardized—and this makes a big difference when you look at the results.

A two-month study had healthy older adults take different doses of a gotu kola extract standardized to a naturally occurring compound called “asiaticoside" or a placebo. At the low dose of 250 mg/day, the group showed significant improvements in reaction time and accuracy of their working memory and subjects also reported feeling calmer.⁷

Water hyssop (Bacopa monnieri)

Bacopa monnieri extract is a very popular study aid, and for good reason. Studies of adults indicate bacopa improves aspects of cognitive function, particularly related to memory.⁸

In elderly volunteers, Bacopa extract improved cognitive function and brain processing speed, including power and continuity of attention as well as the speed and quality of memory formation.⁹ The study clearly demonstrated that regular daily use of bacopa enhanced attention and cognitive processing capability as well as working memory and cholinergic function.⁹

Bacopa isn’t just for older people, however. In a double blind, placebo-controlled study involving 60 healthy medical students (who are considered to have higher than average cognitive capacity), 6 weeks of bacopa significantly improved attention, concentration, recall, and working memory when compared to placebo.¹⁰

So how does Bacopa work? Preclinical studies suggest bacopa encourages new connections between neurons in the parts of your brain associated with learning, memory and emotion.^11,12

Added Benefit of Limonene

The ubiquinone form of CoQ10 is difficult for the body to absorb.¹¹ Super-Absorbable CoQ10™ with d-Limonene provides the ubiquinone form of CoQ10 in a super-emulsified formulation. By adding d-Limonene, a compound in orange peel oil that helps promote the stability of CoQ10, this nutrient stays in your body longer.¹² With this formulation, smaller CoQ10 particles can be released faster in your bloodstream to support optimal CoQ10 absorption and enhance its health benefits. ^12,13

More facts about Super K

Super K provides THREE kinds of vitamin K: vitamin K1 and two forms of K2, menaquinone-4 (MK-4) and menaquinone-7 (MK-7). So taking Super K every day is a good way to make sure you’re getting enough of this essential nutrient for bone and vascular heath.

Bone and arterial health

Vitamin K helps maintain bone density by facilitating the incorporation of calcium into your bones.¹ Vitamin K also supports normal function of a protein called matrix Gla-protein (MGP).² MGP helps regulate how calcium interacts with your arterial walls.³ So in addition to facilitating calcium incorporation into bone, vitamin K helps promote a healthy calcium balance in your arteries as well.

Clinically studied health benefits

The Rotterdam Heart Study is a large-scale clinical study. One report from this study involved 4,800 subjects tracked for at least seven years. It revealed that people who consume more dietary K2 have healthier cardiovascular systems compared with people who consume lower amounts.⁴

Multiple studies have shown vitamin K’s value to maintaining arterial health.^5-8 And vitamin K supplementation is a good way to support healthy bone strength and bone density.⁹

Vitamin K1

The most common form of vitamin K, known as K1, is tightly bound to plant cells in leafy green vegetables. Not only do many people not enjoy these vegetables, but vitamin K from these sources may be poorly absorbed.¹⁰ 

Vitamin K2

In contrast, vitamin K2, which is found in small amounts in cheese, egg yolks and some meats, has been found to be up to eight times more bioavailable than K1 and to remain active in the body for a longer period of time.¹¹  

The MK-4 form of K2 has been shown to be rapidly absorbed, but to only last in the bloodstream for a short time.¹⁰ MK-7, on the other hand, was demonstrated to stay available in the body for up to 48 hours and at much higher levels.¹² And our MK-7 is made from an innovative bio-fermentation process.

Get your daily dose of Vitamin K

Just one daily softgel of Super K provides 100 mcg of vitamin K2 (MK-7); 1,000 mcg of vitamin K2 (MK-4); and 1,500 mcg of vitamin K1.

CoQ10 also has powerful antioxidant properties, protecting cell membranes, important proteins and mitochondrial DNA from oxidative stress.^7,8 Unfortunately, CoQ10 levels in the body decrease over time.^9,10

Improved bioavailability: ubiquinol

The traditional ubiquinone form of CoQ10 is difficult for the body to absorb.¹¹ That's why Life Extension® offers a highly bioavailable form of ubiquinol CoQ10 in a patented delivery system shown to absorb up to 8 times better than ubiquinone.^12,13 In people taking this form of ubiquinol, high levels of plasma CoQ10 were achieved in only four weeks.¹⁴

Shilajit enhances CoQ10 effectiveness

Shilajit is a nutrient discovered in the Himalayas. In preclinical models, shilajit has been shown to promote mitochondrial energy production and increase adenosine triphosphate (ATP), which is the main source of cellular energy.^15,16 The combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain—45% better than CoQ10 alone. Muscle tissue saw a 144% increase in ATP, more than 50% better than with CoQ10 by itself.¹⁵

CoQ10 and aging

With increasing age, in addition to declining CoQ10 levels, the body’s ability to convert ubiquinone into active ubiquinol declines.¹⁷ In a pre-clinical model, ubiquinol was up to 40% more effective at slowing measurements of aging compared with ubiquinone.¹⁸ 

PQQ promotes growth of new mitochondria

PQQ (pyrroloquinoline quinone) is a nutrient that promotes the production of new mitochondria. In fact, PQQ promotes youthful cellular function in three distinct ways:

• Promotes mitochondrial biogenesis. PQQ activates genes that promote the formation of fresh mitochondria. It also beneficially interacts with genes directly involved in mitochondrial health.¹⁹
• Mitochondrial support. PQQ’s antioxidant potency and favorable gene-expression profile act to support mitochondrial defense.²⁰
• Antioxidant power. PQQ is a potent antioxidant, and its molecular stability enables PQQ to facilitate thousands of antioxidant reactions in the mitochondria, without breaking down, for maximum antioxidant and bioenergetic support.²¹

But a green tea break isn’t in the cards for everyone—in fact, when times are chaotic, you’re even less likely to take time for tea time. That’s why we created Theanine XR™ Stress Relief. Our formula delivers 400 mg of green tea’s famous amino acid L-theanine over a six-hour period to promote a prolonged state of wakeful relaxation, helping the body manage daytime stress.

L-theanine and a calm state of mind

L-theanine can cross the blood-brain barrier where it’s been shown to help protect brain areas associated with your stress response from oxidative stress. It also helps modulate the activity of excitatory neurotransmitters like glutamate and increase levels of GABA, another neurotransmitter which helps keep the mind calm and relaxed—especially when you’re having “one of those days.”

Why is this L-theanine formula extended release?

Your body metabolizes l-theanine quickly. In fact, you’d need to drink several cups of green tea throughout the day to maintain a steady supply of l-theanine—and green tea by itself contains very low levels of theanine. But extended-release technology allows our Theanine XR™ Stress Relief to stay in your body for up to six hours, giving the body a steady supply of this stress-modulating amino acid.

Suggested Use: One tablet daily or as directed

This decrease in uric acid levels enabled 89% of the participants who were taking the extract to achieve targeted uric acid serum levels.

Further, evidence from pre-clinical studies suggest that the bioactive compounds in T. bellerica may also help support a healthy response to inflammatory factors and has antioxidant properties.^2,3

Vinpocetine is known to encourage optimal brain blood supply, support the ability to retain and recall information, help maintain concentration and support oxygen & glucose use by the brain.^1-4

Several clinical trials have demonstrated that vinpocetine supplementation can support healthy brain blood flow, memory, concentration, and overall cognitive function.^1-4

When taken orally, vinpocetine is easily absorbed.^5,6