Brain Support and Nootropics

Vinpocetine is known to encourage optimal brain blood supply, support the ability to retain and recall information, help maintain concentration and support oxygen & glucose use by the brain.^1-4

Several clinical trials have demonstrated that vinpocetine supplementation can support healthy brain blood flow, memory, concentration, and overall cognitive function.^1-4

When taken orally, vinpocetine is easily absorbed.^5,6

CoQ10 also has powerful antioxidant properties, protecting cell membranes, important proteins and mitochondrial DNA from oxidative stress.^7,8 Unfortunately, CoQ10 levels in the body decrease over time.^9,10

Improved bioavailability: ubiquinol

The traditional ubiquinone form of CoQ10 is difficult for the body to absorb.¹¹ That's why Life Extension® offers a highly bioavailable form of ubiquinol CoQ10 in a patented delivery system shown to absorb up to 8 times better than ubiquinone.^12,13 In people taking this form of ubiquinol, high levels of plasma CoQ10 were achieved in only four weeks.¹⁴

Shilajit enhances CoQ10 effectiveness

Shilajit is a nutrient discovered in the Himalayas. In preclinical models, shilajit has been shown to promote mitochondrial energy production and increase adenosine triphosphate (ATP), which is the main source of cellular energy.^15,16 The combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain—45% better than CoQ10 alone. Muscle tissue saw a 144% increase in ATP, more than 50% better than with CoQ10 by itself.¹⁵

CoQ10 and aging

With increasing age, in addition to declining CoQ10 levels, the body’s ability to convert ubiquinone into active ubiquinol declines.¹⁷ In a pre-clinical model, ubiquinol was up to 40% more effective at slowing measurements of aging compared with ubiquinone.¹⁸ 

PQQ promotes growth of new mitochondria

PQQ (pyrroloquinoline quinone) is a nutrient that promotes the production of new mitochondria. In fact, PQQ promotes youthful cellular function in three distinct ways:

• Promotes mitochondrial biogenesis. PQQ activates genes that promote the formation of fresh mitochondria. It also beneficially interacts with genes directly involved in mitochondrial health.¹⁹
• Mitochondrial support. PQQ’s antioxidant potency and favorable gene-expression profile act to support mitochondrial defense.²⁰
• Antioxidant power. PQQ is a potent antioxidant, and its molecular stability enables PQQ to facilitate thousands of antioxidant reactions in the mitochondria, without breaking down, for maximum antioxidant and bioenergetic support.²¹

Mitochondria are as fascinating as they are essential: They have their own set of DNA. Even the growth of new mitochondria has a name: “mitochondrial biogenesis.” Mitochondrial biogenesis is key to maintaining youthful cellular energy production. PQQ also supports mitochondrial biogenesis and encourages healthy cellular energy levels in 3 distinct ways:

Mitochondrial DNA & antioxidant protection

The enormous amount of cellular energy generated within mitochondria also exposes them to constant free radical activity. Fortunately, PQQ is a potent antioxidant, offering powerful free radical protection and maximum support for cellular energy production at the same time.⁵

Mitochondria possess their own DNA, which is different from the DNA found in a cell’s nucleus. Unfortunately, mitochondrial DNA is more vulnerable to mutations than nuclear DNA. PQQ's antioxidant potency and favorable gene expression profile help to support delicate mitochondrial DNA against oxidation.

Favorable gene expression

PQQ activates genes that promote the formation of new mitochondria.¹⁰ PQQ also beneficially interacts with genes directly involved in mitochondrial health. These same genes also support healthy sugar and fat metabolism, youthful cellular proliferation and more.^6,7,11

Other potential whole-body health benefits

PQQ may support quality, restful sleep, heart health and cognitive function, by itself and in combination with CoQ10.^8-13 Plus, when taken with CoQ10, PQQ promotes memory, attention and cognition in maturing individuals.

Acetyl-L-carnitine supplementation has been shown to benefit energy-intensive body systems such as the nervous system and the cardiovascular system, and to help counteract the age-related increase in oxidative stress and the decrease in mitochondrial efficiency that occurs with advancing years.^1-5

Acetyl-l-carnitine has wide-ranging benefits for nervous system wellness, including the central and peripheral nervous systems, and cognitive health, as well as positive mood.^6-11 It has been shown to promote peripheral nervous system comfort, support healthy mood, energy and overall well-being.^12-17