Inflammation Support

More facts about Discomfort Relief

An estimated 144 million U.S. adults report having experienced some kind of pain in the previous three months.¹ That's where Discomfort Relief comes in: Palmitoylethanolamide is a fascinating fatty acid that can help inhibit occasional discomfort.²

PEA in clinical studies

PEA’s efficacy has been demonstrated in multiple clinical trials.^3-5 For example: In a controlled trial that randomized 636 patients to placebo or PEA for three weeks, 600 mg of PEA every day significantly improved scores on assessments of relative comfort.⁶

Convenient chewable tablets

Discomfort Relief is a supplement that combines 600 mg of PEA in a convenient, berry-flavored chewable tablet. Chew one or two a day to relieve occasional minor pain and discomfort.

Turmeric, Boswellia and black sesame seed oil

Turmeric and Boswellia both inhibit inflammatory factors to help support muscle, bone and joint health. And a 2020 study shows that combining these two extracts with black sesame makes them even more effective. The clinically-studied combination of these three extracts helped relief joint, bone and muscle discomfort—in as little as two and a half hours.¹

What did the study find?

In a seven-day randomized, active-controlled study, participants were given a combination of black sesame seed oil, turmeric and Boswellia extracts. On day one, participants taking the sesame, turmeric and Boswellia blend reported comfort relief within two hours and a half. And by day seven, there was a 72% reduction in total discomfort.¹

Next time discomfort’s got you down, reach for Fast Acting Relief formula—and kick occasional discomfort to the curb!

We have spent years searching for a superior, highly bioavailable form of curcumin, one that delivers maximum health benefits so you can thrive. To do this, we needed to find a technology that protected curcuminoids during digestion and delivered more free curcuminoids per dose.

Fenugreek helps inhibit conjugation

Once in the body, curcuminoid compounds undergo conjugation, a normal chemical reaction where one compound attaches to another. This is problematic because conjugated curcuminoids do not necessarily provide the same health benefits as non-conjugated ones.^1,2

Advanced Curcumin Elite™ protects curcuminoids from conjugation by combining curcumin with galactomannans, a type of fiber derived from fenugreek seeds. Clinical and pre-clinical data shows that doing so produces 45.5 times more bioavailability and broader tissue distribution of free curcuminoids than unformulated curcumin.^3,4

In a clinical study, more than 70% of total plasma curcuminoids were still in their free form five hours after ingestion.⁴ That translates into more comprehensive whole-body health support from the curcumin supplement.

Turmerones and ginger

We’ve added several plant compounds to Advanced Curcumin Elite™ to enhance health benefits of this supplement. Standardized ginger compounds and turmerones from turmeric oil complement curcumin’s ability to help promote a healthy inflammatory response and enhance curcumin’s other health benefits as well.^5,6

Superior curcumin, responsibly sourced

The total amount of free curcuminoids delivered by standard curcumin (such as the one in our previous formulation) is low. So, we’ve made the switch to Advanced Curcumin Elite™ in order to provide our best possible curcumin supplement to our customers.

It is also worth noting that curcumin in Advanced Curcumin Elite™ is sourced from a multitude of responsible farming collectives in India. Advanced Curcumin Elite™ is then made via FenuMAT™, a patented, environmentally friendly, water-based extraction technology (no solvents or chemicals) during which it is combined with fenugreek fiber.

Health benefits of curcumin

Helps inhibit inflammatory factors to support joint and organ health—Curcumin extract helps inhibits inflammatory factors to promote joint and vital organ health.^7,8 Curcumin also inhibits the metabolism of arachidonic acid, as well as the activities of cyclooxygenase, lipoxygenase and cytokines to promote a healthy inflammatory response.^9-11

Brain & immune system health—Curcumin extract inhibits inflammatory factors in the body to promote immune system health.^12-14 Curcumin can also benefit your mind: Studies suggest that curcumin supports healthy brain function and offers neuro-protective benefits.^9,15-17

Digestive, joint & pancreatic health—Evidence suggests that curcumin helps promote healthy bowel function and joint health.^18-21 Curcumin also supports healthy pancreatic function by encouraging pancreatic islet health.^9,22

Cellular support against free radicals—Curcumin provides cellular protection against free radicals.^23-25 Curcumin also supports healthy cholesterol levels already within normal range and helps inhibit inflammation to promote cardiovascular health and more.^9,26

Combining black cumin with turmeric

Curcumin is an extract of turmeric. It is a potent nutrient packed with compounds called curcuminoids known to help inhibit inflammation to support healthy heart and joint health, as well as encourage a healthy immune response.^17-21 Our new, proprietary Curcumin Elite™ turmeric extract has 45 times more free curcuminoids and over 270 times more total curcuminoids than standard turmeric extracts.²² That translates to more health benefits for your entire body.

Supports a healthy inflammatory response

Black cumin seed oil has been shown to support the body’s healthy inflammation response by moderating the effect of critical cell-signaling chemicals and hormone-like messengers.^6,8,11,15 Maintaining healthy cell signaling as you age is key to both a healthy inflammatory response as well as immune system function.^2,23

The free curcuminoids in turmeric extract promote the body’s healthy inflammation response as well.^18,19 They also help inhibit inflammatory factors like arachidonic acid, cyclooxygenase, lipoxygenase, and cytokine compounds to support heart health, brain health and whole-body health.^16,24,25

Boosts the immune system

Black cumin seed oil also supports the body’s natural defenses by encouraging optimal function of a healthy immune system. It does this by helping to maintain the vital defensive activities of macrophages and helper T-cells that work together to bolster your immune system.^15,26-30 Curcumin further promotes immune system health and supports a healthy inflammatory response.^31-34

Two essential functions in one supplement

Black Cumin Seed Oil and Curcumin Elite™ from Life Extension® helps you maintain a healthy immune system and promotes a healthy inflammation response with a single, convenient supplement formula. Plus, we’ve recently upgraded our formula to include ultra-bioavailable Curcumin Elite™, which has much better absorption than standard curcumin.