Cardiovascular Health

Produce more ATP with D-ribose

D-ribose, a carbohydrate molecule found in every living organism, is essential in encouraging the production of ATP. In studies of healthy athletes, D-ribose supplementation has been shown to support exercise capacity and recovery. By helping to support cellular energy production, D-ribose may be especially beneficial for promoting heart health.

The vegan, non-GMO Bioenergy RIBOSE® in our D-Ribose Tablets may help support exercise endurance and cellular energy production and maintain healthy energy levels in heart and muscle tissue.

Produce more ATP with D-ribose

D-ribose, a carbohydrate molecule found in every living organism, is essential in encouraging the production of ATP. In studies of healthy athletes, D-ribose supplementation has been shown to support exercise capacity and recovery. By helping to support cellular energy production, D-ribose may be especially beneficial for promoting heart health.

This formulation combines vitamins B2 (riboflavin), B6 (pyridoxal 5’-phosphate), B12 (as methylcobalamin) and folate as L-5-methyltetrahydrofolate (L-5-MTHF).

Folate (L-5-MTHF)

Folate helps maintain homocysteine levels within the normal range, which promotes cardiovascular health.^1,7,8 Folate supports neurotransmitter synthesis as well, which is an essential part of cognitive health.⁹ People with healthy homocysteine levels have a greater chance of maintaining healthy cognitive function.^10,11

But not everyone’s body can utilize traditional folate supplements. Research shows that a large part of the population cannot convert folate to its bioactive 5-MTHF form (L-5-methyltetrahydrofolate), leaving many vulnerable to low blood folate levels (and higher-than-desired homocysteine).¹² So Homocysteine Resist delivers 8500 mcg of 5-MTHF in each capsule.

Vitamin B6 (pyridoxal 5'-phosphate)

Vitamin B6 also facilitates neurotransmitter synthesis, as well as amino acid and lipid metabolism.⁹ Traditional forms of B6 must be converted to pyridoxal 5'-phosphate before your body can use it, but Homocysteine Resist contains 100 mg of pyridoxal 5'-phosphate that’s ready to work right from the start.⁹

Vitamin B2 (riboflavin) and Vitamin B12 (methylcobalamin)

The body naturally converts vitamin B2 (riboflavin) to its riboflavin-5'-phosphate form, which it then uses for energy production.¹³ Vitamin B12 supports nerve cell growth and heart health by helping to maintain healthy homocysteine levels already within normal range.^14,15 And methylcobalamin is the form of B12 biologically active in your brain.¹⁶

Magnesium also helps maintain already-healthy blood pressure levels.²

Brain & nervous system health

Magnesium plays an important role in the nervous system and helps support healthy brain function. Magnesium can also modulate the signaling of serotonin and other neurotransmitters, and adequate magnesium intake may promote a healthy mood.^3,4

Bone health & density

Magnesium, along with calcium and other minerals, is an essential component of a healthy bone matrix. A well-mineralized bone matrix helps maintain strong, healthy bones.⁵

Metabolic health & more

Magnesium intake also promotes a wide range of healthy metabolic factors, serum lipid profiles and more.^6,7 Magnesium helps protect against oxidative stress, as well.⁸

Mitochondria are as fascinating as they are essential: They have their own set of DNA. Even the growth of new mitochondria has a name: “mitochondrial biogenesis.” Mitochondrial biogenesis is key to maintaining youthful cellular energy production. PQQ also supports mitochondrial biogenesis and encourages healthy cellular energy levels in 3 distinct ways:

Mitochondrial DNA & antioxidant protection

The enormous amount of cellular energy generated within mitochondria also exposes them to constant free radical activity. Fortunately, PQQ is a potent antioxidant, offering powerful free radical protection and maximum support for cellular energy production at the same time.⁵

Mitochondria possess their own DNA, which is different from the DNA found in a cell’s nucleus. Unfortunately, mitochondrial DNA is more vulnerable to mutations than nuclear DNA. PQQ's antioxidant potency and favorable gene expression profile help to support delicate mitochondrial DNA against oxidation.

Favorable gene expression

PQQ activates genes that promote the formation of new mitochondria.¹⁰ PQQ also beneficially interacts with genes directly involved in mitochondrial health. These same genes also support healthy sugar and fat metabolism, youthful cellular proliferation and more.^6,7,11

Other potential whole-body health benefits

PQQ may support quality, restful sleep, heart health and cognitive function, by itself and in combination with CoQ10.^8-13 Plus, when taken with CoQ10, PQQ promotes memory, attention and cognition in maturing individuals.

Added Benefit of Limonene

The ubiquinone form of CoQ10 is difficult for the body to absorb.¹¹ Super-Absorbable CoQ10™ with d-Limonene provides the ubiquinone form of CoQ10 in a super-emulsified formulation. By adding d-Limonene, a compound in orange peel oil that helps promote the stability of CoQ10, this nutrient stays in your body longer.¹² With this formulation, smaller CoQ10 particles can be released faster in your bloodstream to support optimal CoQ10 absorption and enhance its health benefits. ^12,13

CoQ10 also has powerful antioxidant properties, protecting cell membranes, important proteins and mitochondrial DNA from oxidative stress.^7,8 Unfortunately, CoQ10 levels in the body decrease over time.^9,10

Improved bioavailability: ubiquinol

The traditional ubiquinone form of CoQ10 is difficult for the body to absorb.¹¹ That's why Life Extension® offers a highly bioavailable form of ubiquinol CoQ10 in a patented delivery system shown to absorb up to 8 times better than ubiquinone.^12,13 In people taking this form of ubiquinol, high levels of plasma CoQ10 were achieved in only four weeks.¹⁴

Shilajit enhances CoQ10 effectiveness

Shilajit is a nutrient discovered in the Himalayas. In preclinical models, shilajit has been shown to promote mitochondrial energy production and increase adenosine triphosphate (ATP), which is the main source of cellular energy.^15,16 The combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain—45% better than CoQ10 alone. Muscle tissue saw a 144% increase in ATP, more than 50% better than with CoQ10 by itself.¹⁵

CoQ10 and aging

With increasing age, in addition to declining CoQ10 levels, the body’s ability to convert ubiquinone into active ubiquinol declines.¹⁷ In a pre-clinical model, ubiquinol was up to 40% more effective at slowing measurements of aging compared with ubiquinone.¹⁸ 

PQQ promotes growth of new mitochondria

PQQ (pyrroloquinoline quinone) is a nutrient that promotes the production of new mitochondria. In fact, PQQ promotes youthful cellular function in three distinct ways:

• Promotes mitochondrial biogenesis. PQQ activates genes that promote the formation of fresh mitochondria. It also beneficially interacts with genes directly involved in mitochondrial health.¹⁹
• Mitochondrial support. PQQ’s antioxidant potency and favorable gene-expression profile act to support mitochondrial defense.²⁰
• Antioxidant power. PQQ is a potent antioxidant, and its molecular stability enables PQQ to facilitate thousands of antioxidant reactions in the mitochondria, without breaking down, for maximum antioxidant and bioenergetic support.²¹

Iodine is a trace element essential for the production of thyroid hormones, and vitamin K is an essential nutrient that promotes both arterial and bone health.

Iodine is essential for thyroid health

Iodine is a trace element necessary for the production of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).¹ Iodine is abundant in seafood and sea vegetables, but not everyone likes or has access to marine foods, and vegan diets sometimes lack adequate iodine.²

Commercial salt makers add iodine to table salt to make up for this potential deficiency. However, we now know the health risks of eating too much salt, so health-conscious people may miss out on an easy source of iodine. Vitamins D and K with Sea-Iodine™ delivers 1,000 mcg of iodine to support healthy iodine levels.

Vitamin K1 and two different types of K2

Vitamin K helps inhibit calcium buildup in your arteries while promoting healthy calcium absorption into your bone matrix.³ K1 is the most common form of vitamin K in the diet, coming primarily from leafy green vegetables—though vitamin K1 isn’t well absorbed from these foods.

Vitamin K2 is found in cheese, eggs and fermented soybeans. It has been shown to be more bioavailable than K1 and to remain active in the body far longer. The MK-4 and MK-7 forms of vitamin K2 also provide important benefits but have different tissue distributions and bioavailability, so it’s important to take both.^4,5 This formula contains both forms of vitamin K2.

Vitamin D3 for cognitive, bone and immune health

Healthy serum vitamin D levels have been shown to correspond with better cognitive function.^6,7 Vitamin D, along with vitamin K and essential minerals, is necessary for facilitating the transport of calcium into the bone matrix for strong, healthy bones and teeth.⁸ Vitamin D also plays a critical role in healthy immune function.⁹

Some people may need 125 mcg (5,000 IU) to 200 mcg (8,000 IU) of vitamin D3 a day to achieve healthy blood levels of vitamin D. If your multivitamin already delivers 25-75 mcg (1,000–3,000 IU) of vitamin D, adding Vitamins D and K with Sea-Iodine™ may help achieve healthy vitamin D levels.

Vitamin D3 for heart health and blood pressure support

Vitamin D promotes a healthy inflammatory response, supports cardiovascular health and encourages healthy endothelial function. Vitamin D also helps inhibit excess renin levels. Healthy renin levels help maintain healthy blood pressure already within the normal range.¹⁰

Getting enough vitamins D and K and iodine

This vitamin D3 supplement delivers 125 mcg (5,000 IU) of vitamin D3 as cholecalciferol per capsule. We suggest that you take a 25-hydroxy vitamin D blood test after 3 months to assess and adjust your dosage. Your optimal blood levels should be 50–80 ng/ml year-round.

Ensure you get enough of these three essential nutrients with Vitamins D and K with Sea-Iodine™.